Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9323915 | 0.89 | PLA2G2A (0.56) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9166914 | 0.88 | PLA2G2A (0.57) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9167645 | 0.88 | CNR2 (0.53) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9402583 | 0.86 | PLA2G2A (0.52) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9162948 | 0.85 | PLA2G2A (0.54) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9323980 | 0.85 | PLA2G2A (0.72) | PLA2G2ATSHRPLA2G4BPTPN11TP53 | |
| SCHEMBL9343792 | 0.85 | TDP1 (0.58) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL30036044 | 0.84 | PLA2G2A (0.53) | PLA2G2ATSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL9326297 | 0.84 | NPC1 (0.52) | TSHRALDH1A1CYP3A4MAPK1TDP1 | |
| SCHEMBL8537139 | 0.84 | NPC1 (0.52) | TSHRALDH1A1CYP3A4MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |