Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325910 | 0.86 | ADRA2A (0.43) | TSHRADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325885 | 0.84 | ADRA2A (0.35) | TSHRADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8766326 | 0.82 | TSHR (0.33) | TSHRADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325689 | 0.82 | CYP2E1 (0.35) | ADRA2AADRA2BADRA2CADRA1BCYP2C9 | |
| SCHEMBL9324684 | 0.77 | HPGDS (0.40) | CYP2C9CYP2C19 | |
| SCHEMBL9325667 | 0.72 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B | |
| Hydrochloric Acid SCHEMBL9325923 | 0.71 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9324722 | 0.71 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1BMEN1 | |
| SCHEMBL9325735 | 0.70 | ADRA2A (0.42) | TSHRADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9326720 | 0.68 | NPSR1 (0.40) | TSHRADRA1BLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | claimed |
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | disclosed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | disclosed |