Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325885 | 0.88 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL9324682 | 0.86 | TSHR (0.35) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL9324722 | 0.84 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1BMEN1 | |
| SCHEMBL8766326 | 0.84 | TSHR (0.33) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL9325735 | 0.83 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL9325930 | 0.79 | HPGDS (0.40) | ADRA2AADRA2BADRA2CADRA1BCYP2C9 | |
| SCHEMBL31034854 | 0.76 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034887 | 0.76 | POLB (0.41) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL31034870 | 0.76 | FAAH (0.39) | ADRA2AADRA2BADRA2CADRA1BTSHR | |
| SCHEMBL31034900 | 0.74 | FAAH (0.43) | ADRA2AADRA2BADRA2CADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | claimed |
| JP-2202874-A | — | — | None | — | — | JP | disclosed |
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | disclosed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |
| JP-H02202874-A | SUBSTITUTED IMIDAZOLE, PREPARATION THEROF AND DRUG COMPOSITION CONTAINING SAME AS EFFECTIVE COMPONENT | FARMOS YHTYMAE OY | 1990-08-10 | — | — | JP | disclosed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | disclosed |