Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 7/20 | 0.32 |
| ▸ | CPB1 | P15086 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325735 | 0.88 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325910 | 0.84 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CADRA1BMEN1 | |
| SCHEMBL9325930 | 0.83 | HPGDS (0.40) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325707 | 0.80 | CYP2E1 (0.35) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325689 | 0.77 | CYP2E1 (0.35) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325885 | 0.75 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CADRA1BMEN1 | |
| SCHEMBL9325876 | 0.75 | CYP2E1 (0.34) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034854 | 0.73 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034887 | 0.72 | POLB (0.41) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034870 | 0.72 | FAAH (0.39) | ADRA2AADRA2BADRA2CADRA1BCPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |
| CN-1023219-C | Substituted imidazole derivatives and their preparation and use | FARMOS OY (FI) | 1993-12-22 | — | — | CN | disclosed |
| CN-1043128-A | The imdazole derivatives and the preparation thereof that replace | FARMOS OY (FI) | 1990-06-20 | — | — | CN | disclosed |