Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932636 | 0.76 | ALDH1A1 (0.50) | ALDH1A1POLBLMNAKMT2AMEN1 | |
| SCHEMBL932795 | 0.75 | LMNA (0.42) | GAAKDM4EPOLBLMNAKMT2A | |
| SCHEMBL1101965 | 0.75 | ALDH1A1 (0.79) | GAAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL9950819 | 0.73 | GAA (1.00) | GAAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL932174 | 0.73 | MCOLN3 (0.50) | GAAALDH1A1RAB9ALMNATSHR | |
| SCHEMBL932971 | 0.73 | MCOLN3 (0.58) | GAAALDH1A1LMNATSHRKMT2A | |
| SCHEMBL22834120 | 0.72 | ALDH1A1 (0.79) | GAAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL788790 | 0.71 | ALDH1A1 (0.77) | GAAALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL931510 | 0.71 | PKM (0.59) | GAAALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL932415 | 0.71 | LMNA (0.53) | ALDH1A1KDM4ELMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448581-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002816-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |