Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | LDLR | P01130 | 1/20 | 0.31 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31034847 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BIDO1 | |
| SCHEMBL9326469 | 0.84 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325531 | 0.83 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1BIDO1 | |
| SCHEMBL9324661 | 0.75 | NPSR1 (0.40) | IDO1HTR2CALDH1A1NPSR1 | |
| SCHEMBL9327773 | 0.72 | NPSR1 (0.38) | IDO1HTR2CALDH1A1NPSR1 | |
| SCHEMBL9326644 | 0.72 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL3904093 | 0.69 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BIDO1 | |
| SCHEMBL9325910 | 0.69 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CADRA1BALDH1A1 | |
| Atipamezole SCHEMBL304971 | 0.67 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1B | |
| Atipamezole SCHEMBL29357620 | 0.67 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |