Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325531 | 0.88 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1BHTR7 | |
| SCHEMBL9326469 | 0.80 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9326821 | 0.76 | NPSR1 (0.37) | ADRA1BHTR7HTR6 | |
| SCHEMBL9324769 | 0.75 | CYP11B2 (0.46) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034847 | 0.72 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325913 | 0.72 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL9325707 | 0.69 | CYP2E1 (0.35) | ADRA2AADRA2BADRA2CADRA1BQPCT | |
| SCHEMBL18826054 | 0.68 | ADRA2A (0.78) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325885 | 0.67 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL3904093 | 0.66 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | disclosed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |