Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692935 | 0.87 | HDAC1 (0.78) | ALDH1A1HDAC1HDAC8POLBTDP1 | |
| SCHEMBL9326251 | 0.86 | ALDH1A1 (0.85) | ALDH1A1HDAC1HDAC8POLBTDP1 | |
| SCHEMBL9324159 | 0.86 | HDAC1 (0.64) | ALDH1A1HDAC1HDAC8POLBTDP1 | |
| SCHEMBL10460529 | 0.84 | ALDH1A1 (0.72) | ALDH1A1TBXA2RTBXAS1 | |
| SCHEMBL2691131 | 0.83 | HDAC1 (0.78) | ALDH1A1HDAC1HDAC8POLBTDP1 | |
| SCHEMBL9325241 | 0.83 | ALDH1A1 (0.63) | ALDH1A1HDAC1HDAC8POLBTDP1 | |
| SCHEMBL5120002 | 0.82 | SLC10A6 (0.62) | PRMT1 | |
| SCHEMBL3558356 | 0.82 | WDR5 (0.63) | ALDH1A1HDAC1HDAC8CES1PRMT1 | |
| SCHEMBL27812546 | 0.82 | FFAR1 (0.74) | ALDH1A1CES1PRMT1POLBTDP1 | |
| SCHEMBL9656043 | 0.81 | TBXAS1 (0.51) | ALDH1A1CES1PRMT1TBXA2RTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280043-A | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1994-01-18 | — | — | US | claimed |
| EP-0365183-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-02-10 | — | — | EP | claimed |
| EP-0365183-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-04-25 | — | — | EP | claimed |
| US-5280043-A | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1994-01-18 | — | — | US | disclosed |
| EP-0365183-B1 | BIOLOGICALLY ACTIVE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-02-10 | — | — | EP | disclosed |
| EP-0365183-A1 | Biologically active compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-04-25 | — | — | EP | disclosed |