Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19505485 | 0.79 | SIGMAR1 (0.71) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL22431584 | 0.78 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL9327633 | 0.76 | KCNH2 (0.50) | SIGMAR1ALDH1A1KCNH2 | |
| SCHEMBL19498802 | 0.76 | SIGMAR1 (0.69) | SIGMAR1ALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL22431515 | 0.76 | SIGMAR1 (0.69) | SIGMAR1ALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL9327453 | 0.76 | KCNH2 (0.55) | SIGMAR1ALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL22431451 | 0.75 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1 | |
| SCHEMBL9383002 | 0.75 | TSHR (0.53) | SIGMAR1ALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL9383251 | 0.74 | ALDH1A1 (0.53) | ALDH1A1KMT2AKCNH2 | |
| SCHEMBL19505660 | 0.74 | SIGMAR1 (0.69) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |