Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327453 | 0.93 | KCNH2 (0.55) | KCNH2SIGMAR1KCNJ1TSHRMAPT | |
| SCHEMBL9325771 | 0.86 | KCNH2 (0.50) | KCNH2SIGMAR1KCNJ1TSHRMAPT | |
| SCHEMBL9324433 | 0.83 | SIGMAR1 (0.39) | KCNH2SIGMAR1TSHRMAPT | |
| SCHEMBL9325748 | 0.82 | KCNH2 (0.49) | KCNH2MAPTALDH1A1 | |
| SCHEMBL9326379 | 0.82 | KCNH2 (0.50) | KCNH2MAPTALDH1A1 | |
| SCHEMBL9325778 | 0.80 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL9324472 | 0.79 | CA1 (0.42) | SIGMAR1MAPTALDH1A1 | |
| SCHEMBL9324382 | 0.79 | KDM4E (0.39) | KCNH2SIGMAR1ALDH1A1 | |
| SCHEMBL9324328 | 0.79 | TMEM97 (0.48) | SIGMAR1MAPTALDH1A1 | |
| SCHEMBL9325692 | 0.77 | HTR2A (0.36) | KCNH2TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | claimed |
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |