Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327633 | 0.93 | KCNH2 (0.50) | KCNH2MAPTALDH1A1SIGMAR1KCNJ1 | |
| SCHEMBL9325771 | 0.83 | KCNH2 (0.50) | KCNH2MAPTKMT2ADRD2DRD3 | |
| SCHEMBL9325455 | 0.83 | HTR2A (0.39) | KCNH2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL11222756 | 0.79 | KCNH2 (0.71) | KCNH2MAPTALDH1A1THRATHRB | |
| SCHEMBL10531084 | 0.78 | KCNH2 (0.63) | KCNH2MAPTALDH1A1THRATHRB | |
| SCHEMBL9325778 | 0.77 | KCNH2 (0.67) | KCNH2DRD2DRD3 | |
| SCHEMBL9326502 | 0.76 | SIGMAR1 (0.48) | KCNH2MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL9324433 | 0.75 | SIGMAR1 (0.39) | KCNH2MAPTDRD2DRD3SIGMAR1 | |
| SCHEMBL10531208 | 0.75 | KCNH2 (0.65) | KCNH2MAPTALDH1A1KCNJ1TSHR | |
| SCHEMBL9325748 | 0.74 | KCNH2 (0.49) | KCNH2MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |