Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 9/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904093 | 0.89 | ADRA2A (0.50) | CYP11B2CYP11B1IDO1ADRA2AADRA2B | |
| SCHEMBL9325531 | 0.86 | ADRA2A (0.49) | CYP11B2CYP11B1IDO1ADRA2AADRA2B | |
| SCHEMBL9326469 | 0.83 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL31034847 | 0.79 | ADRA2A (0.50) | IDO1ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325913 | 0.79 | ADRA2A (0.50) | IDO1ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9326644 | 0.75 | ADRA2A (0.40) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325930 | 0.70 | HPGDS (0.40) | CYP11B2CYP11B1ADRA2AADRA2BADRA2C | |
| SCHEMBL27984850 | 0.68 | CYP11B1 (0.62) | CYP11B2CYP11B1IDO1HPGDSP2RX7 | |
| SCHEMBL6496747 | 0.68 | CYP11B1 (0.63) | CYP11B2CYP11B1IDO1HPGDSP2RX7 | |
| SCHEMBL9413343 | 0.66 | CYP11B1 (0.62) | CYP11B2CYP11B1IDO1HPGDSP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | claimed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | claimed |
| EP-0372954-A1 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÀ OY (FI) | 1990-06-13 | — | — | EP | claimed |