Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.36 |
| ▸ | CTSD | P07339 | 3/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932399 | 0.76 | BACE1 (0.53) | BACE1KCNH2BACE2CYP3A4CTSE | |
| SCHEMBL931327 | 0.76 | BACE1 (0.53) | BACE1KCNH2BACE2CYP3A4CTSE | |
| SCHEMBL931861 | 0.76 | BACE1 (0.53) | BACE1KCNH2BACE2CYP3A4CTSE | |
| SCHEMBL3686002 | 0.61 | KDM1A (0.55) | MAOBMAOA | |
| SCHEMBL931601 | 0.61 | BACE1 (0.50) | BACE1KCNH2BACE2 | |
| SCHEMBL6922254 | 0.58 | BACE1 (0.69) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932572 | 0.58 | BACE1 (0.69) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL21895378 | 0.58 | FABP7 (0.46) | CYP3A4 | |
| SCHEMBL8766773 | 0.57 | HSD11B1 (0.56) | BACE1PRMT5CTSDWDR77BACE2 | |
| SCHEMBL14667567 | 0.57 | ALDH1A1 (0.54) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |