Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945501 | 0.85 | BACE1 (0.47) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL931802 | 0.84 | BACE1 (0.38) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL946218 | 0.83 | BACE1 (0.49) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932230 | 0.72 | BACE1 (0.59) | BACE1KCNH2BACE2 | |
| SCHEMBL931281 | 0.70 | BACE1 (0.60) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932073 | 0.69 | BACE1 (0.59) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL6891103 | 0.69 | BACE1 (0.56) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932626 | 0.69 | BACE1 (0.65) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL932141 | 0.67 | BACE1 (0.45) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL931210 | 0.67 | BACE1 (0.47) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |