Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 5/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6894146 | 0.86 | BACE1 (0.56) | BACE1NPSR1APPMEN1KMT2A | |
| SCHEMBL6892288 | 0.86 | BACE1 (0.67) | BACE1APPIDO1MEN1KMT2A | |
| SCHEMBL946696 | 0.84 | BACE1 (0.46) | BACE1NPSR1APPIDO1AGXT | |
| SCHEMBL931863 | 0.83 | BACE1 (0.46) | BACE1NPSR1APPIDO1AGXT | |
| SCHEMBL932309 | 0.83 | BACE1 (0.44) | BACE1APPKCNH2CTSD | |
| SCHEMBL931592 | 0.79 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL932732 | 0.79 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL932046 | 0.77 | BACE1 (0.60) | BACE1APPKCNH2CTSD | |
| SCHEMBL945358 | 0.74 | BACE1 (0.58) | BACE1APPKCNH2CTSD | |
| SCHEMBL932274 | 0.73 | BACE1 (0.43) | BACE1NPSR1APPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |