Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.67 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932777 | 0.86 | BACE1 (0.65) | BACE1IDO1KCNH2TAAR1APP | |
| SCHEMBL931592 | 0.81 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL932732 | 0.81 | BACE1 (1.00) | BACE1KCNH2 | |
| SCHEMBL6894146 | 0.73 | BACE1 (0.56) | BACE1GAAKCNH2APPALDH1A1 | |
| SCHEMBL946696 | 0.69 | BACE1 (0.46) | BACE1IDO1TAAR1APPMEN1 | |
| SCHEMBL932309 | 0.68 | BACE1 (0.44) | BACE1KCNH2APPALDH1A1 | |
| SCHEMBL932046 | 0.62 | BACE1 (0.60) | BACE1KCNH2APP | |
| Diphenylmethane SCHEMBL3723822 | 0.60 | ACHE (0.60) | IDO1TAAR1MEN1KMT2A | |
| SCHEMBL14048355 | 0.60 | ACHE (0.46) | BACE1TAAR1ALDH1A1TDP1 | |
| M-Xylene SCHEMBL28110820 | 0.60 | ACHE (0.67) | GAATAAR1ALDH1A1TDP1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |