Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547165 | 1.00 | ATM (0.50) | ATMPOLBMMECYP19A1SIGMAR1 | |
| SCHEMBL7233850 | 1.00 | ATM (0.50) | ATMPOLBMMECYP19A1SIGMAR1 | |
| SCHEMBL5494161 | 1.00 | ATM (0.50) | ATMPOLBMMECYP19A1SIGMAR1 | |
| SCHEMBL7597723 | 1.00 | ATM (0.50) | ATMPOLBMMECYP19A1SIGMAR1 | |
| SCHEMBL28339063 | 0.87 | RAB9A (0.38) | ATMCYP19A1SIGMAR1CHRM1RAB9A | |
| SCHEMBL8582244 | 0.84 | ALDH1A1 (0.48) | ATMPOLBCYP19A1SIGMAR1MEN1 | |
| SCHEMBL4637454 | 0.84 | ALDH1A1 (0.48) | ATMPOLBCYP19A1SIGMAR1MEN1 | |
| SCHEMBL8582242 | 0.84 | ALDH1A1 (0.48) | ATMPOLBCYP19A1SIGMAR1MEN1 | |
| SCHEMBL6772112 | 0.83 | POLB (0.36) | ATMPOLBCYP19A1SIGMAR1 | |
| SCHEMBL9386896 | 0.81 | ATM (0.36) | ATMCYP19A1SIGMAR1CHRM1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322952-A | Pyrrolidine derivatives and process for preparing the same | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-06-21 | — | — | US | disclosed |