Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 4/20 | 0.56 |
| ▸ | RECQL | P46063 | 4/20 | 0.56 |
| ▸ | BLM | P54132 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | RAD52 | P43351 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12270728 | 0.99 | MAPT (0.56) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL13588290 | 0.99 | MAPT (0.56) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL8943182 | 0.99 | MAPT (0.56) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL9664808 | 0.95 | MAPT (0.56) | MAPTMEN1KMT2ATHRBRECQL | |
| Water SCHEMBL11530647 | 0.95 | MAPT (0.53) | MAPTMEN1KMT2ATHRBRECQL | |
| Pyridine SCHEMBL10522884 | 0.94 | MAPT (0.52) | MAPTMEN1KMT2ATHRBRECQL | |
| Pyridine SCHEMBL5078591 | 0.94 | MAPT (0.52) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL9317740 | 0.92 | MAPT (0.55) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL14072247 | 0.92 | MAPT (0.53) | MAPTMEN1KMT2ATHRBRECQL | |
| SCHEMBL13653474 | 0.91 | MAPT (0.50) | MAPTMEN1KMT2ATHRBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0232101-B1 | Light-sensitive silver halide color photographic material | KONISHIROKU PHOTO IND (JP) | 1994-03-23 | — | — | EP | disclosed |
| US-4994361-A | With specific yellow coupler | KONICA CORPORATION (JP) | 1991-02-19 | — | — | US | disclosed |
| US-4988614-A | Magenta color forming sulfonamidophenol for images | KONICA CORPORATION (JP) | 1991-01-29 | — | — | US | disclosed |
| EP-0371767-A2 | Silver halide color photographic light-sentitie material | KONICA CORPORATION (JP) | 1990-06-06 | — | — | EP | disclosed |
| EP-0361897-A2 | Silver halide color photographic light-sensitive material containing novel magenta couplers | KONICA CORPORATION (JP) | 1990-04-04 | — | — | EP | disclosed |
| EP-0232101-A2 | Light-sensitive silver halide color photographic material | KONICA CORPORATION (JP) | 1987-08-12 | — | — | EP | disclosed |
| US-4564587-A | Light-sensitive silver halide color photographic material comprising multi-silver halide emulsion layers having same color sensitiveness but different in sensitivities | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-01-14 | — | — | US | disclosed |
| US-4521507-A | REDUCE SCATTERING OF LIGHT BY SIZE OF GRAINS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-06-04 | — | — | US | disclosed |
| US-RE31893-E | DEVELOPMENT INHIBITOR WITH AMINO GROUP AND DEVELOPMENT INHIBITOR WITHOUT AMINO GROUP | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-05-21 | — | — | US | disclosed |
| US-4438194-A | HIGH SENSITIVITY, GOOD GRAININESS AND GRADATION | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
| US-4414308-A | Silver halide color photographic photosensitive material | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1983-11-08 | — | — | US | disclosed |
| EP-0083239-A2 | Multi-layer light-sensitive silver halide color photographic material | KONICA CORPORATION (JP) | 1983-07-06 | — | — | EP | disclosed |
| US-4370410-A | GREEN LAYER CONTAINS A NONDIFFUSING YELLOW COUPLER; DEVELOPMENT STABILITY; COLOR FILMS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4355100-A | SILVER HALIDE EMULSIONS CONTAINING TWO DEVELOPMENT SUPPRESSORS; ONE HAVING AN AMINO GROUP AND ONE THAT DOES NOT; STORAGE STABILITY | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1982-10-19 | — | — | US | disclosed |
| US-4268622-A | Photographic light-sensitive materials having dyed layers | FUJI PHOTO FILM CO., LTD. (JP) | 1981-05-19 | — | — | US | disclosed |
| US-4171975-A | MAGENTA COUPLER AND AN AMIDE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1979-10-23 | — | — | US | disclosed |
| US-4153460-A | Light-sensitive silver halide color photographic material | KONISHIROKU PHOTO INDUSTRY CO., LTD (JP) | 1979-05-08 | — | — | US | disclosed |