Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RGS12 | O14924 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11714592 | 0.84 | CYP1B1 (0.46) | CYP1B1MAPTKMT2AHTTMEN1 | |
| SCHEMBL11709021 | 0.81 | PRMT1 (0.46) | CYP1B1MAPTKMT2AHTTMEN1 | |
| SCHEMBL9169702 | 0.80 | TYMS (0.48) | CYP1B1MAPTKMT2AMEN1RAB9A | |
| SCHEMBL11718152 | 0.79 | PRMT1 (0.44) | CYP1B1MAPTKMT2AHTTMEN1 | |
| SCHEMBL7706791 | 0.74 | PRMT1 (0.60) | CYP1B1MAPTKMT2AHTTMEN1 | |
| SCHEMBL17736787 | 0.72 | HTR1A (0.44) | MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9437179 | 0.71 | CYP1B1 (0.62) | CYP1B1MAPTKMT2AHTTMEN1 | |
| SCHEMBL7712197 | 0.71 | CYP1B1 (0.65) | CYP1B1MAPTKMT2AMEN1LMNA | |
| SCHEMBL9170601 | 0.70 | L3MBTL1 (0.47) | MAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL416462 | 0.70 | MAPT (0.57) | MAPTLMNAHDAC6RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304549-A | Control or prevention of degenerative joint diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |