Mecloxamine

Mecloxamine

SCHEMBL933263

CC(CN(C)C)OC(C)(c1ccccc1)c1ccc(Cl)cc1.CCC(C)C(C(=O)OC1CCN(C)CC1)c1ccccc1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 5/20 0.41
CHRM2 P08172 2/20 0.40
CHRM4 P08173 2/20 0.40
HRH1 P35367 2/20 0.39
CACNA1C Q13936 2/20 0.39
CHRM1 P11229 2/20 0.39
MLNR O43193 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
OPRM1 P35372 1/20 0.39
DRD3 P35462 1/20 0.39
OPRK1 P41145 1/20 0.39
HTR2B P41595 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KCNH2 Q12809 1/20 0.39
CYP3A4 P08684 2/20 0.37
MEN1 O00255 2/20 0.37
GMNN O75496 2/20 0.37
LMNA P02545 2/20 0.37
BLM P54132 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pentapiperide SCHEMBL25997 0.80 MEN1 (0.51) CHRM3CHRM2CHRM4HRH1CACNA1C
Mecloxamine SCHEMBL249953 0.73 BCL2 (0.43) CHRM3CHRM2CHRM4HRH1CACNA1C
Mecloxamine SCHEMBL5705589 0.69 MAPT (0.41) KCNH2CYP3A4MEN1GMNNLMNA
Pentapiperium SCHEMBL1222217 0.66 CHRM3 (0.66) CHRM3CHRM2CHRM4CHRM1MEN1
Pentapiperium SCHEMBL454024 0.65 CHRM3 (0.64) CHRM3CHRM2CHRM4CHRM1MEN1
SCHEMBL343231 0.64 CYP2D6 (0.71) CHRM3CHRM2CHRM4CHRM1OPRM1
SCHEMBL17294736 0.63 CYP2D6 (0.68) CHRM3CHRM2CHRM4CHRM1OPRM1
SCHEMBL17294776 0.63 CYP2D6 (0.68) CHRM3CHRM2CHRM4CHRM1OPRM1
SCHEMBL17294730 0.63 CYP2D6 (0.68) CHRM3CHRM2CHRM4CHRM1OPRM1
SCHEMBL5072788 0.62 CHRM2 (0.70) CHRM3CHRM2CHRM4HRH1CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011005352-A1 SUSTAINED-RELEASE DRUG DELIVERY COMPOSITIONS AND METHODS UPM PHARMACEUTICALS, INC. (US) 2011-01-13 WO disclosed
US-20100092562-A1 SUSTAINED-RELEASE DRUG DELIVERY COMPOSITIONS AND METHODS UPM PHARMACEUTICALS, INC. 2010-04-15 US disclosed
WO-2008064163-A2 POLYMER COATED DRUG-ION EXCHANGE RESINS AND METHODS MORTON GROVE PHARMACEUTICALS, INC. (US) 2008-05-29 WO disclosed
US-20080118570-A1 POLYMER COATED DRUG-ION EXCHANGE RESINS AND METHODS WOCKHARDT EU OPERATIONS (SWISS) AG (CH) 2008-05-22 US disclosed
WO-2004087052-A2 OIL-CONTAINING, ORALLY ADMINISTRABLE PHARMACEUTICAL COMPOSITION FOR IMPROVED DELIVERY OF A THERAPEUTIC AGENT LIPOCINE, INC. (US) 2004-10-14 WO disclosed
US-20030235595-A1 Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent LIPOCINE, INC. 2003-12-25 US disclosed
US-5980882-A A SOLID OR A GEL MEDICINE COMPRISING DEXTROMETHORPHAN, CODEINE, MORPHINE, HYDRCODONE, PSEUDOEPHEDRINE, OR PHENYLPROPANOLAMINE AND COMPLEXED WITH CHELATING AGENT SELECTED FROM EDTA OR A SALT OF EDTA; STORAGE STABILITY MEDEVA PHARMACEUTICALS MANUFACTURING (US) 1999-11-09 US disclosed
EP-0911039-A2 Drug-resin complexes stabilized by chelating agents Medeva Pharmaceutical Manufacturing, Inc. (US) 1999-04-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080118570-A1 POLYMER COATED DRUG-ION EXCHANGE RESINS AND METHODS NSF, SEM1, ABCB11 CHRM3 3892/4885CHRM2 3286/4885CHRM4 3379/4885
US-20030235595-A1 Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent LIPA, LIPC, CETP CHRM3 2884/4885CHRM2 2491/4885CHRM4 3369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.