Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17485643 | 0.87 | L3MBTL1 (0.64) | RAB9ALMNAL3MBTL1TSHRDEGS1 | |
| SCHEMBL934440 | 0.85 | RAB9A (0.75) | RAB9ALMNAL3MBTL1TSHRDEGS1 | |
| SCHEMBL18292466 | 0.85 | L3MBTL1 (0.78) | RAB9ALMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL18286246 | 0.84 | RAB9A (0.61) | RAB9ALMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL20284048 | 0.83 | DEGS1 (1.00) | RAB9ALMNAL3MBTL1TSHRDEGS1 | |
| SCHEMBL26986446 | 0.82 | RAB9A (0.71) | RAB9ALMNAL3MBTL1TSHRALDH1A1 | |
| SCHEMBL21286264 | 0.82 | WNT3A (0.78) | RAB9ADEGS1KMT2AMEN1HSD17B10 | |
| SCHEMBL22607250 | 0.82 | KMT2A (0.84) | RAB9ALMNADEGS1ALDH1A1KMT2A | |
| SCHEMBL934578 | 0.82 | KMT2A (0.74) | RAB9ALMNATSHRDEGS1ALDH1A1 | |
| SCHEMBL29385905 | 0.82 | DEGS1 (0.71) | RAB9ALMNAL3MBTL1TSHRDEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008475-A1 | OPTIONALLY SUBSTITUTED 2-(ARYLMETHYL, ARYLOXY OR ARYLTHIO) -N- PYRIDIN-2 -YL-ARYL ACETAMIDE OR 2, 2-BIS (ARYL) -N-PYRIDIN-2-YL ACETAMIDE COMPOUNDS AS MEDICAMENTS FOR THE TREATMENT OF EYE DISEASES | ALLERGAN, INC. (US) | 2011-01-20 | — | — | WO | claimed |