Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | WNT3A | P56704 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18286227 | 0.91 | L3MBTL1 (0.67) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL18286262 | 0.86 | L3MBTL1 (1.00) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL933299 | 0.85 | RAB9A (0.74) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL26986446 | 0.83 | RAB9A (0.71) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL29963496 | 0.83 | KMT2A (0.71) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL12069639 | 0.81 | WNT3A (0.55) | RAB9AL3MBTL1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19763053 | 0.80 | WNT3A (0.74) | RAB9AKMT2AMEN1SMN1; SMN2WNT3A | |
| SCHEMBL29385905 | 0.79 | DEGS1 (0.71) | RAB9AL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL11034892 | 0.79 | TDP1 (0.69) | RAB9AL3MBTL1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL18292431 | 0.78 | L3MBTL1 (0.71) | RAB9AL3MBTL1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011008475-A1 | OPTIONALLY SUBSTITUTED 2-(ARYLMETHYL, ARYLOXY OR ARYLTHIO) -N- PYRIDIN-2 -YL-ARYL ACETAMIDE OR 2, 2-BIS (ARYL) -N-PYRIDIN-2-YL ACETAMIDE COMPOUNDS AS MEDICAMENTS FOR THE TREATMENT OF EYE DISEASES | ALLERGAN, INC. (US) | 2011-01-20 | — | — | WO | claimed |