Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.50 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 3/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333421 | 1.00 | TK1 (0.50) | TK1RNASE1BCHETYMSTERT | |
| SCHEMBL6542150 | 0.88 | RNASE1 (0.61) | TK1RNASE1BCHETYMSTERT | |
| SCHEMBL30698170 | 0.88 | RNASE1 (0.61) | TK1RNASE1BCHETYMSTERT | |
| SCHEMBL9331077 | 0.85 | TK1 (0.56) | TK1BCHEABCG2ABCB1 | |
| SCHEMBL9331081 | 0.85 | TK1 (0.56) | TK1BCHEABCG2ABCB1 | |
| SCHEMBL9477727 | 0.85 | DUT (0.46) | TK1RNASE1TYMSTERTCA12 | |
| SCHEMBL9331399 | 0.85 | DUT (0.46) | TK1RNASE1TYMSTERTCA12 | |
| SCHEMBL9331377 | 0.84 | RNASE1 (0.44) | TK1RNASE1TYMSTERTCA12 | |
| SCHEMBL9476925 | 0.84 | RNASE1 (0.44) | TK1RNASE1TYMSTERTCA12 | |
| SCHEMBL2584183 | 0.81 | TYMS (0.60) | TK1RNASE1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356166-B1 | Therapeutic nucleosides | WELLCOME FOUND (GB) | 1994-04-20 | — | — | EP | disclosed |
| US-5198539-A | Viricides | BURROUGHS WELLCOME CO. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5157114-A | Treatment of HIV infections | BURROUGHS WELLCOME CO. (US) | 1992-10-20 | — | — | US | disclosed |
| EP-0356166-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |