Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335106 | 0.88 | HDAC6 (0.41) | HDAC6PTGER4AKR1B1AKR1A1NPC1 | |
| SCHEMBL9339010 | 0.76 | PTGER4 (0.56) | PTGER4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL362555 | 0.76 | DYRK1A (0.45) | HDAC6PTGER4AKR1B1AKR1A1NPC1 | |
| SCHEMBL28984552 | 0.74 | HDAC6 (0.55) | HDAC6PTGER4AKR1B1AKR1A1NPC1 | |
| SCHEMBL27399288 | 0.70 | NPC1 (0.43) | HDAC6PTGER4AKR1B1AKR1A1NPC1 | |
| SCHEMBL10721825 | 0.69 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6229545 | 0.69 | SMN1; SMN2 (0.56) | HDAC6AKR1B1AKR1A1NPC1RAB9A | |
| SCHEMBL7541753 | 0.69 | DYRK1A (0.56) | HDAC6AKR1B1AKR1A1NPC1RAB9A | |
| SCHEMBL20651365 | 0.68 | NPC1 (0.46) | HDAC6PTGER4AKR1B1AKR1A1NPC1 | |
| SCHEMBL9335092 | 0.68 | HSD17B10 (0.43) | HDAC6PTGER4AKR1B1AKR1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |