Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL20994738 | 1.00 | — | — | |
| Malic Acid SCHEMBL1813216 | 0.97 | CA4 (0.89) | — | |
| Malic Acid SCHEMBL2711210 | 0.97 | CA4 (0.94) | — | |
| Malic Acid SCHEMBL2891377 | 0.97 | CA4 (0.89) | — | |
| Malic Acid SCHEMBL5013575 | 0.94 | CA4 (0.94) | — | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | — | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | — | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | — | |
| Malic Acid SCHEMBL121544 | 0.94 | CA4 (0.94) | — | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 330 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727544-A2 | NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF IN INTRAVENOUS FORMULATIONS AND METHODS OF USE THEREOF | Chromadex Inc. (US) | 2026-04-22 | — | — | EP | claimed |
| US-12558367-B2 | Nicotinamide riboside and derivatives thereof in intravenous formulations and methods of use thereof | ChromaDex Inc. (US) | 2026-02-24 | — | — | US | claimed |
| US-12503713-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-23 | — | — | US | claimed |
| US-12497637-B1 | Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables | Convergent Health Sciences LLC (US) | 2025-12-16 | — | — | US | claimed |
| US-20250275995-A1 | NICOTINAMIDE RIBOSIDE DOSAGE REGIMEN FOR TREATING PARKINSON'S DISEASE | VESTLANDETS INNOVASJONSSELSKAP AS (VIS) (NO) | 2025-09-04 | — | — | US | claimed |
| US-20250255896-A1 | NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF IN INTRAVENOUS FORMULATIONS AND METHODS OF USE THEREOF | ChromaDex Inc. (US) | 2025-08-14 | — | — | US | claimed |
| US-12378279-B2 | Nicotinamide riboside hydrogen malate crystal, and its preparation method and application | Bonte Biological Engineering (Shenzhen) Co., Ltd. (CN) | 2025-08-05 | — | — | US | claimed |
| US-20250243234-A1 | METHOD OF MAKING NICOTINAMIDE RIBOFURANOSIDE SALTS, NICOTINAMIDE RIBOFURANOSIDE SALTS AS SUCH, AND USES THEREOF | BIOSYNTH AG (CH) | 2025-07-31 | — | — | US | claimed |
| US-20250163094-A1 | NICOTINAMIDE RIBOSIDE HYDROGEN MALATE CRYSTAL, AND ITS PREPARATION METHOD AND APPLICATION | BONTAC BIO-ENGINEERING(SHENZHEN) CO., LTD (CN) | 2025-05-22 | — | — | US | claimed |
| EP-4514362-A1 | NICOTINAMIDE RIBOSIDE DOSAGE REGIMEN FOR TREATING PARKINSON'S DISEASE | VESTLANDETS INNOVASJONSSELSKAP AS (VIS) (NO) | 2025-03-05 | — | — | EP | claimed |
| WO-2015162217-A2 | CRYSTALLINE SALTS OF CEPHALOTAXINE AND THEIR USE FOR ITS PURIFICATION INCLUDING ENANTIOMERS | ROBIN JEAN-PIERRE (CH) | 2015-10-29 | — | — | WO | claimed |
| CN-104592008-A | Preparation method of DL-sodium hydrogen malate | ANHUI SEALONG BIOTECHNOLOGY CO LTD | 2015-05-06 | — | — | CN | claimed |
| WO-2014172794-A1 | CALCIUM PHOSPHATE CEMENT COMPOSITION | MATHYS AG BETTLACH (CH) | 2014-10-30 | — | — | WO | claimed |
| US-8431171-B2 | Partially neutralized acid coated food-grade particles | PURAC BIOCHEM B.V. (NL) | 2013-04-30 | — | — | US | claimed |
| US-20130089912-A1 | METHODS AND COMPOSITIONS FOR THE STABILIZATION OF BIOLOGIC MATERIAL | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2013-04-11 | — | — | US | claimed |
| CN-101489414-A | Partially neutralized acid coated food-grade particles | PURAC BIOCHEM BV (NL) | 2009-07-22 | — | — | CN | claimed |
| EP-2037758-A1 | PARTIALLY NEUTRALIZED ACID COATED FOOD-GRADE PARTICLES | PURAC Biochem BV (NL) | 2009-03-25 | — | — | EP | claimed |
| WO-2008006878-A1 | PARTIALLY NEUTRALIZED ACID COATED FOOD-GRADE PARTICLES | PURAC BIOCHEM BV (NL) | 2008-01-17 | — | — | WO | claimed |
| US-20080014312-A1 | Partially neutralized acid coasted food-grade particles | PURAC BIOCHEM B.V. (NL) | 2008-01-17 | — | — | US | claimed |
| US-4268694-A | HYDROLYSIS OF TETRAHALOCYCLOHEXANONE | FISONS LIMITED (GB) | 1981-05-19 | — | — | US | claimed |