Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.40 |
| ▸ | RARG | P13631 | 15/20 | 0.40 |
| ▸ | RARA | P10276 | 13/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.37 |
| ▸ | GABRE | P78334 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488403 | 0.84 | RARB (0.43) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9333999 | 0.84 | RARB (0.56) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9318560 | 0.83 | RARB (0.56) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9334964 | 0.80 | GABRP (0.37) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL30061258 | 0.78 | RARB (0.66) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL4300903 | 0.78 | RARB (0.66) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9526910 | 0.77 | RARB (0.37) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL9006875 | 0.76 | RARB (0.64) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL6445988 | 0.74 | RARB (0.44) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL8037152 | 0.74 | RARA (0.52) | RARBRARGRARACYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346895-A | Treating dermatoses, immunological disorders, wound healing | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0577737-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1994-01-12 | — | — | EP | disclosed |
| WO-1992017471-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-10-15 | — | — | WO | disclosed |