Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY4R | P50391 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335889 | 0.89 | HDAC3 (0.35) | HPGDHDAC3HDAC1NR1H4NPY1R | |
| SCHEMBL9335939 | 0.88 | HDAC3 (0.39) | HDAC3HDAC1ITGB3ITGA2BNR1H4 | |
| SCHEMBL9337573 | 0.81 | POLB (0.52) | HDAC1POLBERAP2LNPEP | |
| Formic Acid SCHEMBL9335859 | 0.79 | POLB (0.48) | POLBERAP2LNPEP | |
| SCHEMBL9335895 | 0.78 | CASR (0.43) | HDAC3ITGB3ITGA2BPOLBERAP2 | |
| SCHEMBL9339324 | 0.78 | HDAC3 (0.35) | HDAC3HDAC1NPY1RNPY4RPOLB | |
| SCHEMBL12518601 | 0.77 | MMP2 (0.43) | S1PR1NPY1RNPY4RPOLB | |
| SCHEMBL12514977 | 0.77 | MMP2 (0.43) | S1PR1NPY1RNPY4RPOLB | |
| SCHEMBL19944726 | 0.75 | SIRT5 (0.42) | NPY1RNPY4RPOLB | |
| SCHEMBL19219789 | 0.75 | SIRT5 (0.42) | NPY1RNPY4RPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372486-B1 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | HOFFMANN LA ROCHE (CH) | 1994-06-01 | — | — | EP | claimed |