Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339653 | 0.86 | HTR2A (0.45) | SLC6A4SLC6A2CYP2D6MEN1KMT2A | |
| SCHEMBL9341939 | 0.80 | SLC6A4 (0.45) | SLC6A4SLC6A2CYP2D6NOS2CYP3A4 | |
| SCHEMBL9342579 | 0.78 | ALDH1A1 (0.33) | SLC6A4SLC6A2CYP2D6MEN1KMT2A | |
| SCHEMBL9339474 | 0.77 | TP53 (0.38) | SLC6A4SLC6A2CYP2D6MEN1KMT2A | |
| Dimethylamine SCHEMBL9337974 | 0.75 | ALDH1A1 (0.40) | CYP2D6MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL9338360 | 0.74 | SLC6A4 (0.36) | SLC6A4SLC6A2CYP2D6MEN1KMT2A | |
| Dimethylamine SCHEMBL9337624 | 0.72 | TSHR (0.40) | CYP2D6TSHRHTR2AHRH1ALDH1A1 | |
| SCHEMBL9338197 | 0.71 | ICMT (0.34) | LMNAALOX12ADRA1AADRA1B | |
| SCHEMBL9342414 | 0.69 | TSHR (0.32) | TSHRLMNA | |
| Dimethylamine SCHEMBL9341629 | 0.67 | SLC6A4 (0.46) | SLC6A4SLC6A2CYP2D6CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5236947-A | Side effect reduction | JOUVEINAL S.A. (FR) | 1993-08-17 | — | — | US | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |