Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335031 | 0.90 | MAPK1 (0.40) | MAPK1ALOX15MAPTLMNATP53 | |
| SCHEMBL9334765 | 0.84 | KMT2A (0.43) | MAPTLMNATP53HPGDALDH1A1 | |
| SCHEMBL9338243 | 0.84 | GABRG2 (0.53) | MAPTLMNAHPGDMTNR1AMTNR1B | |
| SCHEMBL9334779 | 0.80 | TSHR (0.40) | MAPTLMNAHPGDMTNR1AMTNR1B | |
| SCHEMBL9336250 | 0.79 | KDM4E (0.40) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9348092 | 0.79 | ALOX15 (0.43) | MAPK1ALOX15MAPTLMNATP53 | |
| SCHEMBL9343320 | 0.78 | HDAC1 (0.41) | MTNR1AMTNR1BALDH1A1SMN1; SMN2GABRA1 | |
| SCHEMBL9344053 | 0.77 | CHEK1 (0.41) | MTNR1AMTNR1BSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9334389 | 0.77 | TMEM97 (0.43) | MAPTTP53ALDH1A1MEN1KMT2A | |
| SCHEMBL9338427 | 0.76 | ALDH1A1 (0.41) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321021-A | Tricyclic pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-06-14 | — | — | US | disclosed |
| US-5036066-A | Muscle relaxants, anxiolytic agents, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| US-4889848-A | 4-OXO-4H-BENZO(A)QUINOLIZINES; MUSCLE RELAXANTS; SEDATIVES; ANTICONVULSANTS; ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4735940-A | Tricyclic pyridine derivatives and pharmaceutical compositions | HOFFMANN-LA ROCHE INC. (US) | 1988-04-05 | — | — | US | disclosed |