Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 5/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343968 | 0.88 | GABRG2 (0.55) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL9334812 | 0.88 | GABRA1 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL9334779 | 0.87 | TSHR (0.40) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL9338489 | 0.84 | MAPK1 (0.46) | GABRG2GABRB3GABRA3GABRA1KMT2A | |
| SCHEMBL9334305 | 0.84 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL9334536 | 0.83 | GABRG2 (0.50) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL9334388 | 0.82 | GABRG2 (0.47) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL10367683 | 0.82 | MTNR1A (0.41) | GABRG2GABRB3GABRA3GABRA1KMT2A | |
| SCHEMBL9334945 | 0.81 | SLC6A3 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| Hydrochloric Acid SCHEMBL9334880 | 0.81 | L3MBTL1 (0.49) | ALDH1A1MAPTRECQLKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5321021-A | Tricyclic pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-06-14 | — | — | US | disclosed |
| US-5036066-A | Muscle relaxants, anxiolytic agents, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4889848-A | 4-OXO-4H-BENZO(A)QUINOLIZINES; MUSCLE RELAXANTS; SEDATIVES; ANTICONVULSANTS; ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4735940-A | Tricyclic pyridine derivatives and pharmaceutical compositions | HOFFMANN-LA ROCHE INC. (US) | 1988-04-05 | — | — | US | disclosed |