4-Methoxy Chalcone

4-Methoxy Chalcone

SCHEMBL9338705

COc1ccc(/C=C\C(=O)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 1.00
CYP3A4 P08684 1/20 1.00
NFKB1 P19838 1/20 1.00
NFKB2 Q00653 1/20 1.00
RELA Q04206 1/20 1.00
MAOB P27338 8/20 0.88
MAPT P10636 5/20 0.88
KMT2A Q03164 3/20 0.88
MEN1 O00255 2/20 0.88
ALDH1A1 P00352 2/20 0.88
CYP1B1 Q16678 2/20 0.88
HSPD1 P10809 1/20 0.88
TNFRSF1A P19438 1/20 0.88
HSPE1 P61604 1/20 0.88
F3 P13726 2/20 0.84
XDH P47989 2/20 0.79
MAOA P21397 3/20 0.74
RAB9A P51151 2/20 0.74
P4HB P07237 1/20 0.74
CALM1 P0DP23 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Methoxy Chalcone SCHEMBL521906 1.00 BCHE (1.00) BCHECYP3A4NFKB1NFKB2RELA
4-Methoxy Chalcone SCHEMBL1566431 1.00 BCHE (1.00) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL27977337 0.95 BCHE (0.91) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL10017455 0.95 BCHE (0.91) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL3698831 0.95 MAOB (0.97) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL3698834 0.95 MAOB (0.97) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL18972861 0.94 BCHE (0.88) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL1675978 0.93 MAOB (1.00) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL521905 0.93 MAOB (1.00) BCHECYP3A4NFKB1NFKB2RELA
4,4'-Dimethoxychalcone SCHEMBL978243 0.91 F3 (1.00) BCHECYP3A4NFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0328668-B1 NONLINEAR OPTICAL MATERIAL NIPPON OILS & FATS CO LTD (JP) 1994-05-25 EP disclosed
US-4910303-A Cataltyic reaction using N-alkylbis(2-hydroxyalkyl)amine TEXACO CHEMICAL COMPANY (US) 1990-03-20 US disclosed
US-4261988-A ANTICHOLESTEROL AGENTS USED IN ANIMAL HUSBANDRY BAYER AKTIENGESELLSCHAFT (DE) 1981-04-14 US disclosed