4-Methoxy Chalcone

4-Methoxy Chalcone

SCHEMBL521906

COc1ccc(C=CC(=O)c2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 1.00
CYP3A4 P08684 1/20 1.00
NFKB1 P19838 1/20 1.00
NFKB2 Q00653 1/20 1.00
RELA Q04206 1/20 1.00
MAOB P27338 8/20 0.88
MAPT P10636 5/20 0.88
KMT2A Q03164 3/20 0.88
MEN1 O00255 2/20 0.88
ALDH1A1 P00352 2/20 0.88
CYP1B1 Q16678 2/20 0.88
HSPD1 P10809 1/20 0.88
TNFRSF1A P19438 1/20 0.88
HSPE1 P61604 1/20 0.88
F3 P13726 2/20 0.84
XDH P47989 2/20 0.79
MAOA P21397 3/20 0.74
RAB9A P51151 2/20 0.74
P4HB P07237 1/20 0.74
CALM1 P0DP23 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Methoxy Chalcone SCHEMBL9338705 1.00 BCHE (1.00) BCHECYP3A4NFKB1NFKB2RELA
4-Methoxy Chalcone SCHEMBL1566431 1.00 BCHE (1.00) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL27977337 0.95 BCHE (0.91) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL10017455 0.95 BCHE (0.91) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL3698831 0.95 MAOB (0.97) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL3698834 0.95 MAOB (0.97) BCHECYP3A4NFKB1NFKB2RELA
SCHEMBL18972861 0.94 BCHE (0.88) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL1675978 0.93 MAOB (1.00) BCHECYP3A4NFKB1NFKB2RELA
4'-Methoxychalcone SCHEMBL521905 0.93 MAOB (1.00) BCHECYP3A4NFKB1NFKB2RELA
4,4'-Dimethoxychalcone SCHEMBL978243 0.91 F3 (1.00) BCHECYP3A4NFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 278 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12576396-B2 Polynorbornene/carbon black-cross-linked three-dimensional network-immobilized copper/gold (PNBI/CB-Cu/Au) nanocatalyst, and preparation method and use thereof Hubei Engineering University (CN) 2026-03-17 US claimed
US-20240261768-A1 POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF Hubei Engineering University (CN) 2024-08-08 US claimed
CN-117820926-A UV (ultraviolet) coating for water transfer printing and preparation method thereof 景德镇创牌陶瓷文化发展有限公司 2024-04-05 CN claimed
CN-117384199-A Preparation of novel organic aluminum hydrogen compound and preparation method of unsaturated alcohol compound catalyzed by novel organic aluminum hydrogen compound 北京理工大学 2024-01-12 CN claimed
CN-114797976-B Preparation and application of crosslinked norbornene copolymer/carbon black three-dimensional network immobilized bimetallic copper/gold nano catalyst 湖北工程学院 2023-11-17 CN claimed
CN-113620901-B Crown ether derived chiral 1,1 '-bi-2, 2' -naphthol, preparation method and application thereof 杭州师范大学 2023-02-10 CN claimed
CN-115141621-A Oil-based fracturing fluid, multi-stage fracturing method and method for online monitoring productivity of reservoir intervals 中国石油化工股份有限公司 2022-10-04 CN claimed
CN-114797976-A Preparation and application of crosslinked norbornene copolymer/carbon black three-dimensional network immobilized bimetallic copper/gold nano catalyst 湖北工程学院 2022-07-29 CN claimed
US-20220003753-A1 METABOLIC PROFILING FOR THE DIAGNOSIS OF A SUBSET OF IDIOPATHIC AUTISM SPECTRUM DISORDER PATIENTS, ADS PHENOTYPE 1 STALICLA SA (CH) 2022-01-06 US claimed
US-20210401728-A1 Topical Compositions and Methods to Promote Optimal Dermal White Adipose Tissue Composition in Vivo GALANIN IVAN (US) 2021-12-30 US claimed
EP-2376444-A1 A METHOD FOR PREPARING SULFUR-CONTAINING COMPOUNDS The Royal College of Surgeons in Ireland (IE) 2011-10-19 EP claimed
WO-2010066450-A1 A METHOD FOR PREPARING SULFUR-CONTAINING COMPOUNDS THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) 2010-06-17 WO claimed
CN-101591230-A 2,4-dyhydroxyl chalcone derivative, Preparation Method And The Use TIANJIN INST PHARM RESEARCH (CN) 2009-12-02 CN claimed
US-7572831-B2 Composition containing chalcone ANGIOLAB, INC. (KR) 2009-08-11 US claimed
US-20040209952-A1 Composition containing chalcone ANGIOLAB, INC. (KR) 2004-10-21 US claimed
US-6797745-B1 Hot melt inks containing styrene or terpene polymers XEROX CORPORATION 2004-09-28 US claimed
EP-1450777-A1 PHARMACEUTICAL COMPOSITION CONTAINING CHALCONE OR ITS DERIVATIVES FOR MATRIX METALLOPROTEINASE INHIBITORY ACTIVITY Angiolab Inc. (KR) 2004-09-01 EP claimed
WO-2003037315-A1 PHARMACEUTICAL COMPOSITION CONTAINING CHALCONE OR ITS DERIVATIVES FOR MATRIX METALLOPROTEINASE INHIBITORY ACTIVITY ANGIOLAB INC. (KR) 2003-05-08 WO claimed
US-6461417-B1 Ink compositions XEROX CORPORATION 2002-10-08 US claimed
US-6117223-A Hot melt inks containing polyketones XEROX CORPORATION (US) 2000-09-12 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240261768-A1 POLYNORBORNENE/CARBON BLACK-CROSS-LINKED THREE-DIMENSIONAL NETWORK-IMMOBILIZED COPPER/GOLD (PNBI/CB-Cu/Au) NANOCATALYST, AND PREPARATION METHOD AND USE THEREOF AOC3, PNN, RPL23A BCHE 583/4885CYP3A4 1430/4885NFKB1 2314/4885
US-12576396-B2 Polynorbornene/carbon black-cross-linked three-dimensional network-immobilized copper/gold (PNBI/CB-Cu/Au) nanocatalyst, and preparation method and use thereof AOC3, PNN, SOD3 BCHE 1166/4885CYP3A4 1739/4885NFKB1 2135/4885
US-20040209952-A1 Composition containing chalcone MMP25, MMP13, MMP17 BCHE 501/4885CYP3A4 1458/4885NFKB1 1407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.