Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339034 | 1.00 | PLA2G2A (0.45) | PLA2G2AKAT8DYRK1AHSD17B10MAPT | |
| SCHEMBL9339137 | 0.81 | KAT8 (0.50) | PLA2G2AKAT8DYRK1AHSD17B10MAPT | |
| SCHEMBL9334957 | 0.79 | KAT8 (0.48) | KAT8DYRK1AHSD17B10MAPTKDM4E | |
| SCHEMBL9389070 | 0.79 | KAT8 (0.48) | KAT8DYRK1AHSD17B10MAPTKDM4E | |
| SCHEMBL9335020 | 0.75 | KAT8 (0.46) | KAT8DYRK1AHSD17B10MAPTKDM4E | |
| SCHEMBL9335010 | 0.75 | KAT8 (0.46) | KAT8DYRK1AHSD17B10MAPTKDM4E | |
| SCHEMBL9339038 | 0.75 | ALDH1A1 (0.50) | PLA2G2ADYRK1AHSD17B10MAPTKDM4E | |
| SCHEMBL69552 | 0.73 | BACE1 (0.60) | HSD17B10MAPTKDM4EHTTKMT2A | |
| SCHEMBL69553 | 0.73 | BACE1 (0.60) | HSD17B10MAPTKDM4EHTTKMT2A | |
| SCHEMBL27831701 | 0.73 | BACE1 (0.59) | HSD17B10KDM4ELMNAHPGDSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |