Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339245 | 0.97 | CYP4A11 (0.55) | DHFRCYP4A11CYP4F2LOXL2TLR8 | |
| SCHEMBL9341073 | 0.96 | CYP4A11 (0.53) | DHFRCYP4A11CYP4F2LOXL2TLR8 | |
| SCHEMBL9341089 | 0.85 | CYP2D6 (0.53) | DHFRCYP2D6ALDH1A1MEN1MAPT | |
| SCHEMBL9338914 | 0.83 | CYP2D6 (0.56) | DHFRSCNN1ACYP2D6ALDH1A1MEN1 | |
| SCHEMBL9343568 | 0.82 | CYP2D6 (0.55) | DHFRSCNN1ACYP2D6ALDH1A1MEN1 | |
| SCHEMBL21667558 | 0.81 | DHFR (0.57) | DHFRLOXL2TLR8TLR7TP53 | |
| SCHEMBL9850059 | 0.79 | FOLR2 (0.39) | DHFRCYP2D6 | |
| SCHEMBL9850002 | 0.77 | HPGD (0.40) | DHFRALDH1A1LMNAHPGD | |
| SCHEMBL9051507 | 0.77 | CYP4A11 (0.46) | DHFRCYP4A11CYP4F2LOXL2TLR8 | |
| SCHEMBL12176878 | 0.76 | CYP4A11 (0.70) | CYP4A11CYP4F2LOXL2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325343-B1 | L-glutamic acid derivatives | UNIV PRINCETON (US) | 1994-06-22 | — | — | EP | disclosed |
| US-4871743-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0325343-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-26 | — | — | EP | disclosed |