Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 12/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934603 | 0.86 | PSMB5 (0.53) | MKNK1MKNK2TBXAS1LRRK2F2 | |
| SCHEMBL933852 | 0.83 | TBXAS1 (0.60) | TBXAS1LMNA | |
| SCHEMBL933898 | 0.83 | CYP17A1 (0.49) | TBXAS1LRRK2F10PRSS1MMP12 | |
| SCHEMBL26167691 | 0.83 | SRR (0.54) | — | |
| SCHEMBL13878057 | 0.80 | CYP2A6 (0.67) | MKNK1MKNK2CYP2A6 | |
| SCHEMBL12413787 | 0.80 | MKNK1 (0.61) | MKNK1MKNK2CYP2A6 | |
| SCHEMBL13227728 | 0.79 | MKNK1 (0.54) | MKNK1MKNK2CYP2A6TBXAS1LRRK2 | |
| SCHEMBL23514716 | 0.79 | CYP2A6 (0.59) | MKNK1MKNK2CYP2A6 | |
| SCHEMBL7606896 | 0.78 | SLC7A5 (0.56) | MKNK1MKNK2CYP2A6TBXAS1LMNA | |
| SCHEMBL21690091 | 0.78 | SLC7A5 (0.56) | MKNK1MKNK2CYP2A6TBXAS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011006935-A2 | TETRAZOLE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-01-20 | — | — | WO | disclosed |