SCHEMBL9339394

SCHEMBL9339394

CC(C)(C)OC(=O)NCCCCCCC(=O)Nc1cccc(C(=O)NCCC(=O)OCc2ccccc2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.51
CA2 P00918 2/20 0.51
HDAC3 O15379 4/20 0.46
HDAC1 Q13547 4/20 0.46
HDAC6 Q9UBN7 3/20 0.46
HDAC2 Q92769 2/20 0.46
HDAC10 Q969S8 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
HDAC4 P56524 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
HDAC9 Q9UKV0 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
CYP3A4 P08684 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
AURKA O14965 1/20 0.45
GAA P10253 1/20 0.45
RAB9A P51151 1/20 0.45
POLB P06746 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10444691 0.91 HDAC6 (0.49) HDAC3HDAC1HDAC6HDAC2HDAC10
SCHEMBL9867129 0.91 HDAC6 (0.49) HDAC3HDAC1HDAC6HDAC2HDAC10
SCHEMBL9335791 0.90 HTT (0.49) HDAC3HDAC1HDAC6HDAC2HDAC10
SCHEMBL9335874 0.88 PRMT5 (0.51) GAARAB9APAX8
SCHEMBL9865134 0.87 HTT (0.53) L3MBTL1GAARAB9APOLBMAPT
SCHEMBL9865610 0.86 HDAC3 (0.49) HDAC3HDAC1HDAC6HDAC2HDAC10
SCHEMBL9339226 0.85 CA1 (0.48) CA1CA2HDAC3HDAC1HDAC6
SCHEMBL12993342 0.84 RAB9A (0.60) CA1CA2CYP3A4L3MBTL1GAA
SCHEMBL9866050 0.84 GAA (0.54) L3MBTL1GAARAB9APOLBMAPT
SCHEMBL9335827 0.84 CA1 (0.45) CA1CA2HDAC3HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372486-B1 Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines HOFFMANN LA ROCHE (CH) 1994-06-01 EP disclosed
US-5039805-A Novel benzoic and phenylacetic acid derivatives HOFFMANN-LA ROCHE INC. (US) 1991-08-13 US disclosed