Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444691 | 1.00 | HDAC6 (0.49) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9335791 | 0.99 | HTT (0.49) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9865134 | 0.96 | HTT (0.53) | HTTSENP1GAARAB9ASIRT2 | |
| SCHEMBL9866050 | 0.93 | GAA (0.54) | HTTSENP1GAARAB9AMEN1 | |
| SCHEMBL9339394 | 0.91 | CA1 (0.51) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9865066 | 0.88 | HTT (0.57) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9866193 | 0.87 | HTT (0.58) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9879968 | 0.84 | HTT (0.60) | HTTRAB9AMEN1KMT2A | |
| SCHEMBL14264247 | 0.83 | HTT (0.64) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL9867345 | 0.83 | NAMPT (0.52) | HTTSENP1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |