Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335791 | 0.97 | HTT (0.49) | HTTSENP1GAARAB9AMEN1 | |
| SCHEMBL10444691 | 0.96 | HDAC6 (0.49) | HTTSENP1GAARAB9AMEN1 | |
| SCHEMBL9867129 | 0.96 | HDAC6 (0.49) | HTTSENP1GAARAB9AMEN1 | |
| SCHEMBL9866050 | 0.95 | GAA (0.54) | HTTSENP1GAARAB9AMEN1 | |
| SCHEMBL9879968 | 0.87 | HTT (0.60) | HTTRAB9AMEN1KMT2AMAPT | |
| SCHEMBL9339394 | 0.87 | CA1 (0.51) | SENP1GAARAB9AL3MBTL1PAX8 | |
| SCHEMBL9867345 | 0.85 | NAMPT (0.52) | HTTSENP1PAX8ALDH1A1HPGD | |
| SCHEMBL9866193 | 0.84 | HTT (0.58) | HTTRAB9AMEN1KMT2AMAPT | |
| SCHEMBL9865066 | 0.83 | HTT (0.57) | HTTRAB9AMEN1KMT2AMAPT | |
| SCHEMBL9865584 | 0.83 | NAMPT (0.60) | HTTPAX8ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |