Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6742236 | 0.80 | VDR (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL14132068 | 0.76 | TDP1 (0.34) | ALDH1A1POLB | |
| SCHEMBL9729166 | 0.76 | MAPT (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL14131948 | 0.76 | MEN1 (0.36) | ALDH1A1MEN1KMT2APOLBKDM4E | |
| SCHEMBL11779255 | 0.74 | CYP2D6 (0.39) | ALDH1A1HTR1A | |
| SCHEMBL14778433 | 0.74 | CYP2D6 (0.37) | ALDH1A1HTR1ASMN1; SMN2 | |
| SCHEMBL3895160 | 0.71 | CYP2D6 (0.35) | ALDH1A1HTR1ASMN1; SMN2 | |
| SCHEMBL28013476 | 0.71 | ALDH1A1 (0.38) | ALDH1A1HTR1ASMN1; SMN2 | |
| SCHEMBL9341766 | 0.71 | CYP1A2 (0.39) | ALDH1A1HTR1ASMN1; SMN2KDM4E | |
| SCHEMBL11014096 | 0.70 | L3MBTL1 (0.38) | ALDH1A1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |
| EP-0450995-A1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL S.A. (FR) | 1991-10-09 | — | — | EP | disclosed |