SCHEMBL9340504

SCHEMBL9340504

O=Cc1c(F)c(Cl)cc(C(F)(F)F)c1F

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.35
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
KDR P35968 1/20 0.32
EPAS1 Q99814 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10701295 0.81 ALDH1A1 (0.44) MEN1ALDH1A1KMT2ATDP1
SCHEMBL9341639 0.80 KIF11 (0.41) KIF11
SCHEMBL7272272 0.77 MEN1 (0.34) MEN1ALDH1A1KMT2ATDP1
SCHEMBL30480764 0.77 ALDH1A1 (0.39) KIF11MEN1ALDH1A1KMT2ATDP1
SCHEMBL613749 0.77 ALDH1A1 (0.39) KIF11MEN1ALDH1A1KMT2ATDP1
SCHEMBL9340546 0.77 KIF11 (0.42) KIF11ALDH1A1KDR
SCHEMBL6723976 0.77 ALDH1A1 (0.43) KIF11MEN1ALDH1A1KMT2ATDP1
SCHEMBL31165603 0.77 KIF11 (0.35) KIF11
SCHEMBL7071048 0.74 IDO1 (0.33) KDR
SCHEMBL9030271 0.74 MEN1 (0.35) KIF11MEN1ALDH1A1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396987-B1 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1994-06-15 EP claimed
EP-0396987-A2 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1990-11-14 EP claimed
EP-0396987-B1 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1994-06-15 EP disclosed
US-5041683-A Nuclear-fluorinated trifluoromethylbenzaldehydes BAYER AKTIENGESELLSCHAFT (DE) 1991-08-20 US disclosed
EP-0396987-A2 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1990-11-14 EP disclosed