SCHEMBL9340780

SCHEMBL9340780

CCCCCCCCOCCc1cc(-n2nc3ccc(Cl)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
P2RX7 Q99572 1/20 0.31
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6834699 0.96 CNR2 (0.32) NPC1RAB9AP2RX7CNR1CNR2
SCHEMBL4647349 0.90 PTGS2 (0.35) NPC1RAB9ACNR1CNR2
SCHEMBL10880369 0.90 PTGS2 (0.35) NPC1RAB9ACNR1CNR2
SCHEMBL6908032 0.88 NPC1 (0.36) NPC1RAB9A
SCHEMBL9229451 0.87 EPHX2 (0.41) CNR1CNR2
SCHEMBL13030430 0.87 EPHX2 (0.41) CNR1CNR2
SCHEMBL78014 0.87 EPHX2 (0.41) CNR1CNR2
SCHEMBL29403911 0.87 EPHX2 (0.41) CNR1CNR2
SCHEMBL27662700 0.86
SCHEMBL14423818 0.86 NPC1 (0.37) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0337942-B1 Liquid substituted 2H-benzotriazole mixtures CIBA GEIGY AG (CH) 1994-07-06 EP disclosed
US-5240975-A Photostability CIBA-GEIGY CORPORATION (US) 1993-08-31 US disclosed
EP-0189374-B1 LIQUID MIXTURES OF 2-(HYDROXY-3-BRANCHED ALKYL-5-METHYLPHENYL)-2H-BENZOTRIAZOLE, PROCESS FOR THEIR PREPARATION AND STABILIZED COMPOSITIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1992-03-18 EP disclosed
US-5095062-A Photostability CIBA-GEIGY CORPORATION (US) 1992-03-10 US disclosed
US-4973701-A LIGHT STABILIZERS FOR PHOTOGRAPHY AND POLYMERS CIBA-GEIGY CORPORATION (US) 1990-11-27 US disclosed
EP-0337942-A1 Liquid substituted 2H-benzotriazole mixtures CIBA-GEIGY AG (CH) 1989-10-18 EP disclosed
US-4675352-A PHOTOSTABILITY CIBA-GEIGY CORPORATION (US) 1987-06-23 US disclosed
EP-0189374-A2 Liquid mixtures of 2-(hydroxy-3-branched alkyl-5-methylphenyl)-2H-benzotriazole, process for their preparation and stabilized compositions containing them CIBA-GEIGY AG (CH) 1986-07-30 EP disclosed
US-4587346-A ALKYLATION WITH ALKENE AND ACID CATALYST CIBA-GEIGY CORPORATION (US) 1986-05-06 US disclosed