Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGFBP5 | P24593 | 5/20 | 0.39 |
| ▸ | IGFBP3 | P17936 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KCNK2 | O95069 | 6/20 | 0.36 |
| ▸ | KCNK10 | P57789 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499798 | 0.82 | IGFBP5 (0.42) | IGFBP5IGFBP3MAPTTSHRALOX15 | |
| SCHEMBL2904601 | 0.78 | IGFBP3 (0.50) | IGFBP5IGFBP3MAPK1SLC6A2P2RY14 | |
| SCHEMBL9343878 | 0.78 | ALOX15 (0.43) | IGFBP5IGFBP3LMNAMAPTALOX15 | |
| SCHEMBL2909106 | 0.76 | IGFBP5 (0.45) | IGFBP5IGFBP3ALOX15 | |
| SCHEMBL2905794 | 0.76 | IGFBP5 (0.46) | IGFBP5IGFBP3MAPTTSHRALOX15 | |
| SCHEMBL2909353 | 0.75 | DHODH (0.46) | IGFBP5IGFBP3HTTSMN1; SMN2ALOX15 | |
| SCHEMBL2902980 | 0.74 | ALOX15 (0.47) | IGFBP5IGFBP3MAPTTSHRSMN1; SMN2 | |
| 7-Chlorokynurenic Acid SCHEMBL157187 | 0.73 | IGFBP3 (0.47) | IGFBP5IGFBP3 | |
| SCHEMBL2909734 | 0.73 | MCL1 (0.44) | IGFBP5IGFBP3HTTSMN1; SMN2ALOX15 | |
| SCHEMBL9398468 | 0.73 | IGFBP5 (0.43) | IGFBP5IGFBP3MAPTTSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486586-B1 | KYNURENIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FIDIA SPA (IT) | 1994-06-08 | — | — | EP | claimed |
| US-5250541-A | Neurological disorders | FIDIA S.P.A. (IT) | 1993-10-05 | — | — | US | claimed |
| WO-1991001973-A1 | KYNURENIC ACID DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FIDIA S.P.A. (IT) | 1991-02-21 | — | — | WO | claimed |
| US-5250541-A | Neurological disorders | FIDIA S.P.A. (IT) | 1993-10-05 | — | — | US | disclosed |