Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346847 | 0.93 | TSHR (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9349900 | 0.92 | TSHR (0.50) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9344863 | 0.92 | ALOX15 (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9349813 | 0.89 | TSHR (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9344884 | 0.86 | HRH3 (0.40) | HRH3ALDH1A1HPGDKMT2ANFE2L2 | |
| SCHEMBL9349856 | 0.86 | HTR7 (0.49) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9346878 | 0.82 | TSHR (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9345630 | 0.82 | TSHR (0.48) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9345579 | 0.82 | TSHR (0.51) | TSHRALOX15HTR7HTR6HTR1A | |
| SCHEMBL9344872 | 0.82 | TSHR (0.53) | TSHRALOX15HTR7HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5326870-A | Asthma; bronchodilator agents; respiratory system disorders | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1994-07-05 | — | — | US | disclosed |
| EP-0525203-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVE OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1993-02-03 | — | — | EP | disclosed |