Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973711 | 0.82 | MAPK1 (0.38) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL19597423 | 0.78 | MAPT (0.39) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9345478 | 0.78 | MAPK1 (0.35) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7563308 | 0.74 | — | — | |
| SCHEMBL10744265 | 0.73 | RXRA (0.34) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10973292 | 0.73 | L3MBTL1 (0.58) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10977345 | 0.70 | FDPS (0.38) | MAPK1SMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL11240410 | 0.70 | ALDH1A1 (0.38) | MAPK1KMT2AMEN1MAPTL3MBTL1 | |
| SCHEMBL10979388 | 0.69 | NPC1 (0.51) | MAPK1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL10976099 | 0.69 | MAPK1 (0.32) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361185-B1 | 2-halogenomethylthio-substituted pyrimidine derivatives | BAYER AG (DE) | 1994-06-22 | — | — | EP | disclosed |
| US-4978382-A | Insecticides, miticides, nematocides | BAYER AKTIENGESELLSCHAFT (DE) | 1990-12-18 | — | — | US | disclosed |
| EP-0361185-A2 | 2-halogenomethylthio-substituted pyrimidine derivatives | BAYER AG (DE) | 1990-04-04 | — | — | EP | disclosed |
| EP-0033195-B1 | PYRIMIDINE-2-SULPHIDES AND THEIR S-OXIDES FOR USE IN MEDICINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND SUCH COMPOUNDS WHEN NOVEL PER SE | NYEGAARD & CO. A/S (NO) | 1985-12-04 | — | — | EP | disclosed |
| US-4423047-A | INHIBITING ABNORMAL CELL PROLIFERATION | NYEGAARD & CO. A/S (NO) | 1983-12-27 | — | — | US | disclosed |
| EP-0033195-A1 | Pyrimidine-2-sulphides and their S-oxides for use in medicine, pharmaceutical compositions containing them, processes for their preparation and such compounds when novel per se | NYEGAARD & CO. A/S (NO) | 1981-08-05 | — | — | EP | disclosed |