Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.55 |
| ▸ | HTR2B | P41595 | 4/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9345138 | 0.95 | OPRM1 (0.55) | HTR2CHTR2BOPRM1OPRD1OPRK1 | |
| SCHEMBL9345993 | 0.81 | GRIN2B (0.56) | HTR2CHTR2BOPRM1OPRD1OPRK1 | |
| SCHEMBL9341225 | 0.79 | HTR2C (0.51) | HTR2CHTR2BHTR1DHTR7HTR1A | |
| SCHEMBL13533345 | 0.79 | HTR7 (0.66) | HTR2CHTR2BHTR1DHTR7HTR2A | |
| SCHEMBL13533347 | 0.79 | HTR7 (0.66) | HTR2CHTR2BHTR1DHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL9341244 | 0.75 | HTR2C (0.50) | HTR2CHTR2BHTR2AHTR1A | |
| SCHEMBL9342090 | 0.75 | HTR1A (0.47) | HTR2CHTR2BOPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL9342088 | 0.74 | HTR2C (0.55) | HTR2CHTR2BOPRM1OPRD1OPRK1 | |
| SCHEMBL6620989 | 0.74 | GRIN2B (0.62) | HTR2CHTR2BOPRM1OPRD1OPRK1 | |
| SCHEMBL10153496 | 0.73 | HTR2C (0.49) | HTR2CHTR2BOPRM1OPRL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343830-B1 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | LILLY CO ELI (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5026707-A | Antiserotonine agents | ELI LILLY AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0343830-A2 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |