Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346961 | 0.90 | KMT2A (0.60) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| Nicaraven SCHEMBL31420006 | 0.86 | KMT2A (0.66) | LMNAKMT2AMEN1ALDH1A1TP53 | |
| Nicaraven SCHEMBL677580 | 0.86 | KMT2A (0.66) | LMNAKMT2AMEN1ALDH1A1TP53 | |
| Nicaraven SCHEMBL9346555 | 0.82 | LMNA (0.63) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL24567733 | 0.80 | LMNA (0.67) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL21467402 | 0.80 | LMNA (0.67) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL20026567 | 0.79 | ALDH1A1 (0.57) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| Nicaraven SCHEMBL9345376 | 0.79 | KMT2A (0.57) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| Nicaraven SCHEMBL9345911 | 0.79 | KMT2A (0.57) | LMNAKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9346966 | 0.79 | RAB9A (0.63) | LMNAKMT2AMEN1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376185-B1 | Process for purification of 1,2-bis(nicotinamido)propane | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5099022-A | Process for purification of 1,2-bis(nicotinamido)propane | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0376185-A2 | Process for purification of 1,2-bis(nicotinamido)propane | Chugai Seiyaku Kabushiki Kaisha (JP) | 1990-07-04 | — | — | EP | disclosed |