Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 9/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 9/20 | 0.56 |
| ▸ | CACNB1 | Q02641 | 9/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4904835 | 0.84 | NAAA (0.68) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL16598967 | 0.82 | CACNA2D1 (0.59) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL9346942 | 0.80 | MEN1 (0.57) | ALDH1A1MAPK1NPC1KMT2A | |
| SCHEMBL9345400 | 0.79 | NPC1 (0.61) | ALDH1A1MAPK1NPC1KMT2A | |
| SCHEMBL9346536 | 0.78 | IAPP (0.53) | NPC1KMT2A | |
| SCHEMBL2293693 | 0.78 | CACNA1C (0.69) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL9350110 | 0.77 | NPC1 (0.59) | ALDH1A1MAPK1NPC1KMT2A | |
| SCHEMBL10483827 | 0.75 | GAA (0.52) | NPC1 | |
| SCHEMBL9336419 | 0.75 | FKBP1A (0.64) | ALDH1A1MAPK1NPC1KMT2A | |
| SCHEMBL6162758 | 0.74 | CACNA1G (0.85) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333522-B1 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5232923-A | Stimulates production of nerve growth factor; administering for treatment of regressive disorders of the central nervous system | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0333522-A2 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-09-20 | — | — | EP | disclosed |