Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.68 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.60 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.60 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.60 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16598967 | 0.88 | CACNA2D1 (0.59) | NAAACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL9345949 | 0.84 | CACNA2D1 (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL2293693 | 0.83 | CACNA1C (0.69) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL16333764 | 0.82 | NAAA (1.00) | NAAAALDH1A1NPC1TDP1KMT2A | |
| SCHEMBL7131839 | 0.78 | NPC1 (0.86) | NAAAALDH1A1NPC1TDP1KMT2A | |
| SCHEMBL4778274 | 0.77 | DPP4 (0.61) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL6160941 | 0.77 | CACNA1G (0.69) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL6162758 | 0.77 | CACNA1G (0.85) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL5775411 | 0.77 | CACNA2D1 (0.51) | CACNA2D1CACNA1BCACNB1CACNA1CCACNA1H | |
| SCHEMBL10130744 | 0.76 | NPC1 (0.67) | NAAAALDH1A1NPC1TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | NOVARTIS AG | 2008-10-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255149-A1 | Carboxyamine Compounds and Methods of Use Thereof | HNMT, HDAC5, HDAC4 | NAAA 240/4885CACNA2D1 4234/4885CACNA1B 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.