Sugi Predict

Sugi Predict / Compounds / SCHEMBL9345959

SCHEMBL9345959

SCHEMBL9345959

COC(=O)C(C)(F)C(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DGAT1 O75907 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.39
▸ CA2 P00918 1/20 0.36
▸ KCNN4 O15554 1/20 0.36
▸ NOTUM Q6P988 2/20 0.32
▸ LMNA P02545 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ SRC P12931 1/20 0.32
▸ KEAP1 Q14145 1/20 0.32
▸ NFE2L2 Q16236 1/20 0.32
▸ HCAR2 Q8TDS4 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ CTRB1 P17538 1/20 0.31
▸ PDK1 Q15118 1/20 0.31
▸ PDK2 Q15119 1/20 0.31
▸ PDK3 Q15120 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17281569 0.89 DGAT1 (0.39) DGAT1ALDH1A1CA2KCNN4LMNA
SCHEMBL445343 0.86 DGAT1 (0.41) DGAT1ALDH1A1CA2KCNN4LMNA
SCHEMBL226311 0.81 — —
SCHEMBL135961 0.81 — —
SCHEMBL17611270 0.80 DGAT1 (0.37) DGAT1ALDH1A1CA2NOTUMKMT2A
SCHEMBL10826096 0.80 DGAT1 (0.37) DGAT1ALDH1A1GAA
SCHEMBL28035795 0.79 — —
SCHEMBL31058002 0.79 — —
SCHEMBL111507 0.78 — —
SCHEMBL2580230 0.78 DGAT1 (0.42) DGAT1ALDH1A1CA2KCNN4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators GENENTECH, INC. (US) 2026-05-05 — — US disclosed
EP-3760623-B1 TETRAHYDRO-PYRIDO[3,4-B]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF HOFFMANN LA ROCHE (CH) 2026-03-18 — — EP disclosed
US-20250114338-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF GENENTECH, INC. (US) 2025-04-10 — — US disclosed
US-12233052-B2 Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof GENENTECH, INC. (US) 2025-02-25 — — US disclosed
CN-114656464-B 6,7,8, 9-Tetrahydro-3H-pyrazolo [4,3-f ] isoquinoline derivatives useful in the treatment of cancer 阿斯利康(瑞典)有限公司 2024-10-15 — — CN disclosed
CN-118005631-A Tetrahydro-pyrido [3,4-b ] indole estrogen receptor modulators and uses thereof 豪夫迈·罗氏有限公司 2024-05-10 — — CN disclosed
CN-117865872-A Tetrahydro-pyrido [3,4-b ] indole estrogen receptor modulators and uses thereof 豪夫迈·罗氏有限公司 2024-04-12 — — CN disclosed
CN-112375078-B Tetrahydro-pyrido [3,4-b ] indole estrogen receptor modulators and uses thereof 豪夫迈·罗氏有限公司 2023-12-19 — — CN disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS GENENTECH, INC. (US) 2023-05-25 — — US disclosed
EP-3233852-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF F. Hoffmann-La Roche AG (CH) 2017-10-25 — — EP disclosed
US-20170200976-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION AND NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY USING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-13 — — US disclosed
US-20170200976-A1 NON-AQUEOUS ELECTROLYTIC SOLUTION AND NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY USING THE SAME MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-13 — — US disclosed
WO-2016097072-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2016-06-23 — — WO disclosed
US-20160175289-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF GENENTECH, INC. (US) 2016-06-23 — — US disclosed
WO-2016097072-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2016-06-23 — — WO disclosed
US-20160175289-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF GENENTECH, INC. (US) 2016-06-23 — — US disclosed
US-20160175289-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF GENENTECH, INC. (US) 2016-06-23 — — US disclosed
EP-0334966-B1 PROCESS FOR SYNTHESIZING OPTICALLY ACTIVE COMPOUNDS NGK INSULATORS LTD (JP) 1994-08-24 — — EP disclosed
EP-0334966-A1 PROCESS FOR SYNTHESIZING OPTICALLY ACTIVE COMPOUNDS NGK INSULATORS, LTD. (JP) 1989-10-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12233052-B2 Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof ESR2, GPER1, ESR1 DGAT1 4533/4885ALDH1A1 1250/4885CA2 2288/4885
US-20250114338-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF ESR2, GPER1, ESR1 DGAT1 4533/4885ALDH1A1 1250/4885CA2 2288/4885
US-20230159555-A1 SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS NLRP3, NLRP1, PYCARD DGAT1 4095/4885ALDH1A1 2491/4885CA2 3131/4885
US-12617802-B2 Sulfonimidamide compounds as NLRP3 modulators NLRP3, NLRP1, PYCARD DGAT1 4786/4885ALDH1A1 2022/4885CA2 1313/4885
US-20160175289-A1 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF ESR2, GPER1, ESR1 DGAT1 4533/4885ALDH1A1 1250/4885CA2 2288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.