Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348780 | 0.87 | POLB (0.38) | POLBHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL9332557 | 0.82 | CHRM3 (0.37) | ALDH1A1SSTR4MAPTLMNASSTR1 | |
| SCHEMBL9345022 | 0.79 | POLB (0.38) | POLBHSD17B10ALDH1A1SSTR4LMNA | |
| SCHEMBL9329945 | 0.73 | SSTR4 (0.57) | SSTR4SSTR1 | |
| SCHEMBL9345043 | 0.73 | ITGB3 (0.34) | POLBALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL9329952 | 0.73 | SMN1; SMN2 (0.45) | POLBALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8277379 | 0.72 | POLB (0.51) | POLBHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL9348740 | 0.71 | DRD2 (0.40) | POLBALDH1A1TSHRLMNASMN1; SMN2 | |
| SCHEMBL9329979 | 0.71 | THRB (0.30) | — | |
| SCHEMBL9499920 | 0.70 | ALDH1A1 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |